abstract：:'The climate is perfect for a proactive search for partners between industry and academia.' ...

journal_title：Drug discovery today

authors： Dean P

更新日期：2000-09-01 00:00:00

abstract：:Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevan...

journal_title：Drug discovery today

authors： Lloyd AW

更新日期：2000-09-01 00:00:00

abstract：:Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevan...

journal_title：Drug discovery today

authors： Lloyd AW

更新日期：2000-08-01 00:00:00

abstract：:Although respiratory syncytial virus (RSV) was discovered in 1955, the burden associated with this infectious agent on all population groups is only now beginning to be fully appreciated. The successful launch of the humanized monoclonal antibody Synagis (developed by MedImmune, Gaithersburg, MD, USA), as a prophylact...

journal_title：Drug discovery today

authors： Meanwell NA,Krystal M

更新日期：2000-06-01 00:00:00

abstract：:The sequencing of the human genome and numerous pathogen genomes has resulted in an explosion of potential drug targets. These targets represent both an unprecedented opportunity and a technological challenge for the pharmaceutical industry. A new strategy is required to initiate small-molecule drug discovery with set...

journal_title：Drug discovery today

authors： Lenz GR,Nash HM,Jindal S

更新日期：2000-04-01 00:00:00

abstract：:Monitor provides an insight into the latest developments in drug discovery through brief synopses of recent presentations and publications together with expert commentaries on the latest technologies. There are two sections: Molecules summarizes the chemistry and the pharmacological significance and biological relevan...

journal_title：Drug discovery today

authors： Lloyd AW

更新日期：1999-11-01 00:00:00

abstract：:Cocaine is a major drug of abuse whose devastating effects have captured the attention of health officials and policy makers. Based upon the alarming health and crime-related costs associated with the use of this powerful reinforcing drug, immediate therapies are needed for the treatment of cocaine addiction. In this ...

journal_title：Drug discovery today

authors： Smith MP,Hoepping A,Johnson KM,Trzcinska M,Kozikowski AP

更新日期：1999-07-01 00:00:00

abstract：:We have recently developed a novel strategy for the rational design of compounds. This 'in silico screening' approach is based on the design and screening of virtual combinatorial libraries. Screening is performed using defined rules derived from a comprehensive description of active and inactive molecules in a releva...

journal_title：Drug discovery today

authors： Gorse D,Rees A,Kaczorek M,Lahana R

更新日期：1999-06-01 00:00:00

abstract：:In therapeutic areas aimed at developing an orally administered drug, the pharmacokinetic profile of a drug candidate after oral administration in vivo is pivotal in evaluating its success. This can be done by monitoring the plasma concentration versus time after dosing and calculating the area under the curve (AUC). ...

journal_title：Drug discovery today

authors： Cox KA,Dunn-Meynell K,Korfmacher WA,Broske L,Nomeir AA,Lin CC,Cayen MN,Barr WH

更新日期：1999-05-01 00:00:00

abstract：:Chemokines are proinflammatory mediators that primarily control leukocyte migration into selected tissues and upregulation of adhesion receptors. They also have a role in pathological conditions that require neovascularization and are implicated in the suppression of viral replication. By interaction with their respec...

journal_title：Drug discovery today

authors： Saunders J,Tarby CM

更新日期：1999-02-01 00:00:00

abstract：:Since being introduced to the field of drug discovery at Zeneca Pharmaceuticals in 1991, it has become apparent to me that a blizzard of revolutionary novel approaches has swept through the pharmaceutical industry. Now, the discovery process has become completely transformed and the race to develop commercially succes...

journal_title：Drug discovery today

authors： Tranter D

更新日期：1999-01-01 00:00:00